Cellulose fibers, such as cotton, exhibit good recyclability; however, the recycling of protein-based fibers, such as wool, presents significant challenges. These challenges primarily stem from the low molecular weight and complex hierarchical structure of protein fibers. In this presentation, we will discuss our recent advancements in the chemical recycling of protein-based fibers, focusing on the challenges and limitations associated with these processes. Two approaches were investigated for wool textile recycling: (1) direct dissolution of wool in an ionic liquid alongside cellulose for fiber spinning and (2) extraction of keratin using a urea-SDS-cysteine solvent system, followed by its redissolution with cellulose in an ionic liquid for fiber spinning. The latter approach proved more versatile for mixed textile waste and resulted in the production of more homogeneous regenerated hybrid fibers. The regenerated hybrid fibers were characterized for mechanical properties, crystalline structure, fibrillation, hydrophobicity, and dyeability to evaluate their performance and potential applications.