Biopolymers, Biomaterials

Release of active ingredients from porous fibers

Saal A
Freitag, 13.09.2024, 11:00 - 11:25 Uhr

The release of drugs from textile drug delivery systems has still not been realized satisfactorily. Local therapy, i.e. the delivery of the drug by the textile medical device itself, can be significantly more effective if the drug is released in sufficient quantities where a local effect is to be achieved. Triggered drug release, which is based on the use of a drug-filled matrix within porous fibers, enables the drug to be administered on demand and in a controllable manner.

Sprecher
Andreas Scherrieble (DITF Deutsche Institute für Textil- und Faserforschung Denkendorf)
Co-Authoren
Carsten Linti (DITF Deutsche Institute für Textil- und Faserforschung Denkendorf), Reinhold Schneider (DITF Deutsche Institute für Textil- und Faserforschung Denkendorf)
The release of drugs from textile drug delivery systems has still not been realized satisfactorily. Local therapy, i.e. the delivery of the drug by the textile medical device itself, can be significantly more effective if the drug is released in sufficient quantities where a local effect is to be achieved. Strategies for controlled drug release based on the use of a drug-filled matrix within porous fibers are presented. The porous fibers generated for this purpose are produced by melt spinning of various compounds and subsequently dissolving out the water-soluble component. The properties of the porous fibers are optimally adapted to the release of the active ingredient. The on-demand and controllable triggering of the release of the active ingredient from the matrix is achieved by adding thermoreversible gelling polymers, which release the active ingredient as a result of phase separation when a critical temperature is exceeded. Polymers based on poly-N-isopropylacrylamide (PNIPA) or PVCL are suitable for this purpose and can be modified in such a way that the switching temperature is in the range of the skin temperature and the release of the active ingredient can be specifically initiated by the application of heat by heating or as a result of inflammation. The release kinetics were demonstrated using Horseradish Peroxidase as a model active ingredient.