Low moisture absorbency of hydrophobically coated flame-resistant (FR) fabrics do not correlate well with the thermophysiological comfort (i.e. moisture transfer to cool the body and reduce the heat by moisture build-up). In this frame, we were the first to study the effect of screen-printing of micro and nano-fibrilated cellulose (native, carboxylated, phosphorylated and quarternized) on the fabric surface to meet these requirements. The pattering of micro/nanocellulose as a function of the printing parameters (type of mesh, squeegee pressure and printing speed) and its durability (attachment) after the subsequent printing of hydrophobic polyacrylate on the same (layer-by-layer) ) or the other side of the fabric will be presented, with the aim of preserving one side of the fabric (facing towards the wearer) hydrophilic, while keeping the other side (facing outwards) hydrophobic. The changing of fabrics properties, abrasion resistance, air permeability and water-vapour resistance, as well as surface wetting and absorbency, will be discussed. The processability of the concept at the industrial level in a roll-to-roll screen-printing machine will be shown. Acknowledgment: This project has received funding from the European Union’s Horizon 2020 research and innovation programme (Grant agreement No. 760601), as well as from the Slovenia Research Agency (Grant agreement No. L2-9249 and research program P2-0424).